CRS and ICANS Treatment

A Phase II Pilot Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to Chimeric Antigen Receptor T-Cell Therapy (CAR-T) in Hematological Malignancies

What's the purpose of the trial?

This study will evaluate the use of siltuximab to decrease the severity of cytokine release syndrome (CRS) and immune effector cell-associated neurological syndrome (ICANS) in patients who will receive chimeric antigen receptor (CAR) T-cell therapy for the treatment of hematological malignancies.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
30
Last Updated
2 weeks ago
Am I Eligible

Participating Centers

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Experimental Treatments

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  • Siltuximab

Arms / Cohorts

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Accepting patients

Siltuximab

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