EXCALIBER RRMM

Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Iberdomide, Daratumumab and Dexamethasone VS Daratumumab, Bortezomib, and Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma

What will happen during the trial?

STAGE 1
Participants in this stage will be randomly assigned into one of four groups. Three of the groups will receive different doses of investigational drug Iberdomide in combination with Daratumumab and Dexamethasone. One group will receive comparator combination of Daratumumab, Bortezomib, and Dexamethasone. The three Iberdomide groups will receive different doses of investigational drug Iberdomide.

STAGE 2
Participants in this stage will be randomized into one of two groups. Group A will receive investigational drug Iberdomide (at the dose selected by stage 1), Daratumumab, and Dexamethasone. Group B will receive the comparator combination of Daratumumab, Bortezomib, and Dexamethasone. 

More Information

Trial Status
Accepting patients
Trial Phase
Phase 3
Enrollment
864 patients (estimated)
Sponsors
Celgene Corporation, a wholly owned subsidiary of Bristol Myers Squibb
Tags
Cereblon E3 Ligase Modulators (CELMoDs), Randomization
Trial Type
Treatment
Last Update
1 week ago
SparkCures ID
1203
NCT Identifier
NCT04975997

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