UNC Lineberger Comprehensive Cancer Center

University of North Carolina

Chapel Hill, NC

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Accepting patients

QUINTESSENTIAL

Phase 2 Study of BMS-986393, a GPRC5D-directed CART-Cell Therapy, in Participants with Relapsed or Refractory Multiple Myeloma
  • CAR T Cell
  • GPRC5D
  • Phase 2

Accepting patients

DREAMM-20

A Phase 1/2 Open-label, Multicentre, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, and Clinical Activity of Belantamab as Monotherapy and in Combination With Other Treatments in Participants With Multiple Myeloma
  • Antibody Drug Conjugate (ADC)
  • BCMA
  • Phase 1/2
  • Has results

Accepting patients

Isatuximab in Frail Patients

Isatuximab Plus Lenalidomide and Dexamethasone for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma
  • Monoclonal Antibody
  • CD38
  • Phase 2

Not currently accepting

Iberdomide vs. Observation Post Ide-Cel CAR-T

Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma
  • CELMoD
  • Randomization
  • Maintenance
  • Phase 2

Accepting patients

TRIgnite-1

A Phase 1, First-in-Human, Multicenter, Open-Label, Dose Escalation and Dose-Expansion Study of Single-Agent ISB 2001 in Subjects With Relapsed/Refractory Multiple Myeloma
  • T Cell
  • Trispecific Antibody
  • BCMA
  • CD38
  • Phase 1
  • Has results

Accepting patients

Horizon Two

Horizon Two: HR NDMM (MMRC-100)
  • T Cell Engager (TCE)
  • Bispecific Antibody
  • CD3
  • BCMA
  • Randomization
  • Maintenance
  • High Risk
  • Phase 2

Accepting patients

FASTER

Frontline T-cell Engager vs Autologous Stem Cell Transplant and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma (FASTER)
  • Autologous Stem Cell Transplant
  • Bispecific Antibody
  • BCMA
  • Phase 2

Accepting patients

OPN-662

A Phase 1b, Dose Escalation/Dose Expansion, Multicenter, Open-Label Study to Assess the Safety and Tolerability of OPN-6602 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and/or Refractory Multiple Myeloma
  • BET Inhibitor
  • Phase 1
  • Has results

Accepting patients

LP-118

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory NHL, RT, MM, T-PLL, Acute Leukemia (AML, ALL), MDS, MDS/MPN, and MF
  • Bcl/xL Inhibitor
  • BCL-2 Inhibitor
  • Phase 1

Not yet accepting

DSP-5336

A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of DSP-5336 Following a Single Oral Dose in Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Myeloproliferative Neoplasms
  • Menin Inhibitor
  • Phase 1
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