Sarah Cannon Research Institute

TriStar Centennial Medical Center

Nashville, TN

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inMMyCAR

A Phase 1 Study to Evaluate the Safety of KLN-1010, a Novel, In Vivo Gene Therapy to Generate Anti-B Cell Maturation Antigen (Anti-BCMA) Chimeric Antigen Receptor-T Cells (CAR-T) in Patients With Relapsed and Refractory Multiple Myeloma
  • CAR T Cell
  • BCMA
  • Phase 1
  • Has results

Accepting patients

DURGA-1

AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)
  • CAR T Cell
  • BCMA
  • CD19
  • Phase 1/2
  • Has results

Accepting patients

Horizon Adaptive Platform

MMRC Horizon One: RRMM (MMRC-099)
  • Bispecific Antibody
  • BCMA
  • CD3
  • Randomization
  • Phase 2

Accepting patients

PF-07994525

An Open-Label Phase 1 Study to Evaluate PF-07994525 in Participants With Advanced Malignancies
  • KAT2 Inhibitor
  • Phase 1

Accepting patients

Etentamig for Newly Diagnosed Patients

Phase 2/3, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Subjects With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
  • Bispecific Antibody
  • CD3
  • BCMA
  • Randomization
  • Phase 2/3

Accepting patients

TRIlogy-3

A Phase 2, Open-label Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti-CD38 Antibody
  • Trispecific Antibody
  • GPRC5D
  • BCMA
  • Phase 2

Accepting patients

Teclistamab or Talquetamab

Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma
  • Bispecific Antibody
  • BCMA
  • Phase 2
  • Has results

Accepting patients

DREAMM-20

A Phase 1/2 Open-label, Multicentre, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, and Clinical Activity of Belantamab as Monotherapy and in Combination With Other Treatments in Participants With Multiple Myeloma
  • Antibody Drug Conjugate (ADC)
  • BCMA
  • Phase 1/2
  • Has results

Accepting patients

mRNA-2808

A Phase 1/2, Open-label, Multicenter Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma
  • GPRC5D
  • BCMA
  • FCRH5
  • Phase 1/2

Accepting patients

FASTER

Frontline T-cell Engager vs Autologous Stem Cell Transplant and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma (FASTER)
  • Autologous Stem Cell Transplant
  • Bispecific Antibody
  • BCMA
  • Phase 2
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